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"Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use.

"You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy." - U.S. National Institutes of Health

"It took the Women’s Health Initiative trial around five years and $150 million to find that estrogen may be a problem after menopause," [Joseph S.] Dillon says. We have no such long-term studies of DHEA." - WebMD®

CategoryExamples of Specific Terms
  Interactions with Drugs  
Liver's enzyme systemCytochrome P450
Central nervous system agentsCarbamazepine and phenytoin
Blood sugar levelsMetformin (Glucophage®), drugs for diabetes by mouth, insulin
Blood clottinganticoagulants (Blood thinners) or antiplatelet drugs (such as aspirin), warfarin (Coumadin®), heparin, and clopidogrel (Plavix®). Also smoking, oral contraceptives or hormone replacement therapy.
Heart rates or rhythmVarious heart medications or drugs, also alcohol.
Calcium channel blockersDiltiazem (Cardizem®) and alprazolam (Xanax®)
Various DrugsCanrenoate, anastrozole (Arimidex®), growth hormones, methylphenidale, amlodipine, nicardipine and other calcium channel blockers like diltiazem (Cardizem®) and alprazolam (Xanax®)
Hormonal therapiesEstrogen or androgen
Psychiatric drugsClozapine (Clozaril®)
Seizures or painGABA-receptor drugs
Influenza vaccinationAntibody titer
  Drugs that Might Affect DHEA Levels  
DecreaseDopamine, insulin, corticosteroids such as dexamethasone, drugs used to treat endometriosis such as danazol, opiate painkillers, antipsychotics, and estrogen-containing drugs.
IncreaseMetopirone, alprazolam and benfluorex
  Interactions with Herbs and Dietary Supplements  
Liver's enzyme systemAnything that affects the P450 system
Blood sugar levelsArginine, cocoa, ephedra (when combined with caffeine), melatonin, aloe vera, American ginseng and bilberry
Blood clottingCoenzyme Q10 or Panax ginseng, Ginkgo biloba, garlic, and saw palmetto
Heart rates or rhythmadonis, balloon cotton, and foxglove/digitalis
Hormonal effectsAlfalfa, black cohosh, and bloodroot
  Herbs and Supplement that Might Affect DHEA Levels  
IncreaseChromium picolinate
  Miscellaneous Interactions  
Possibly addictiveCarnitine
VariousMay increase melatonin secretion and prevent breakdown of vitamin E in the body
VariousFiber, flavanoids, polyunsaturated fatty acids, probiotics, soy protein and yam

Summarized from:   U.S. National Institutes of Health
"Many other interactions are possible; check with a qualified healthcare
professional including a pharmacist, for a thorough list."

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Want more? See the Google News Archive for DHEA and interactions.

WorldWide Labs
The content presented in this website is for informational purposes only. Before taking this or any other health supplement or therapy, consult your healthcare professional. Even mild supplements can have varying effects on individuals, and can conflict with your existing medications and diet. See additional information.


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Customer Comments
"I ordered DHEA again, because I promised reorder with you. I sent on-line order 7 bottles of DHEA. Thanks for your kind mail and best service." - KHJ, South Korea

"I appreciate the fact that you responded so quickly. I'm having a physical tomorrow and will have the DHEA levels checked. I'll report any substantial changes if there are any for your records." - S.D.W., USA

"I can say, without reservation, that DHEA is the best drug I have ever taken. You have improved the quality of my life." - C.J., USA

"This is the 4th time I'm ordering from you!!! I'm very glad with this DHEA. Keep up the good work!!!" - N.S., Israel