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Evidence for the Benefits
Summarized from the Mayo Clinic.| Grade of Evidence | Condition | Results |
| Good | Adrenal Insufficiency | May improve well-being, quality of life, exercise capacity, sex drive, and hormone levels in people with insufficient adrenal function (Addisons disease). |
| Good | Depression | Scores support its use for this purpose under the guidance of specialist. |
| Good | Obesity | Support its use for this purpose |
| Good | Systemic Lupus Erythematosus | Support its use as an adjunct treatment. |
| Unclear | Alzheimer's Disease | Does not significantly improve cognitive performance or change symptom severity in patients with Alzheimers disease but some disagree. Additional study is warranted in this area. |
| Unclear | Bone Density | Under investigation. Not yet clear. |
| Unclear | Cardiovascular Disease | Conflicting evidence. |
| Unclear | Cervical Cancer | May promote regression of low-grade cervical lesions. |
| Unclear | Chronic Fatigue Syndrome | Evidence is unclear. |
| Unclear | Cocaine Withdrawal | Preliminary study shows that DHEA is not beneficial. |
| Unclear | Critical Illness | Unclear evidence. |
| Unclear | Crohn's Disease | Suggests possible beneficial effects. |
| Unclear | HIV / AIDS | Conflicting evidence. |
| Unclear | Induction of Labor | May help to induce labor. Do not self-treat. |
| Unclear | Infertility | Conflicting evidence. |
| Unclear | Menopausal Disorders | DHEA cream on the skin may improve vaginal pain and discomfort. DHEA may not be an effective treatment for hot flashes or emotional disturbances. |
| Unclear | Myotonic Dystrophy | Conflicting evidence. |
| Unclear | Psoriasis | Likely offers no benefit. |
| Unclear | Rheumatoid Arthritis | Likely offers no benefit. |
| Unclear | Schizophrenia | Benefits in the management of negative, depressive, and anxiety symptoms of schizophrenia. Some of the side effects from prescription drugs used for schizophrenia may also be relieved. |
| Unclear | Septicemia (serious bacterial infections in the blood) | Unclear evidence. |
| Unclear | Sexual Function / Libido / Erectile Dysfunction | Studies vary. Unclear results. |
| Unclear | Sjogren's Syndrome | No evidence of efficacy. |
| Unclear | Skin Aging | Preliminary study suggests the possibility of using DHEA topically as an anti-skin aging agent. |
| May Not Work | Fibromyalgia (postmenopause) | Does not seem to improve quality of life, pain, fatigue, cognitive function, mood, or functional impairment. |
| May Not Work | Immune System Stimulant | Current evidence is against. |
| May Not Work | Memory | Complex and inconsistent results. Most studies in this area report no benefits. |
| May Not Work | Muscle Strength | Conflicting, overall the evidence is negative |
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Before taking this or any other health supplement or therapy, consult your healthcare professional.
Even mild supplements can have varying effects on individuals, and can conflict with your existing medications and diet.
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